Towards circuit optogenetics
نویسندگان
چکیده
منابع مشابه
Optogenetics and the circuit dynamics of psychiatric disease.
Optogenetics is a method for delivering millisecondprecision control (for activation or inhibition) to targeted cells using light within freely behaving mammals.1 The components of this method, as practiced today, involve (1) lasers and fiber optics for light delivery into the nervous system and (2) genes called microbial opsins, which encode light-activated proteins that regulate transmembrane...
متن کاملIn vivo application of optogenetics for neural circuit analysis.
Optogenetics combines optical and genetic methods to rapidly and reversibly control neural activities or other cellular functions. Using genetic methods, specific cells or anatomical pathways can be sensitized to light through exogenous expression of microbial light activated opsin proteins. Using optical methods, opsin expressing cells can be rapidly and reversibly controlled by pulses of ligh...
متن کاملCardiac optogenetics.
Optogenetics is an emerging technology for optical interrogation and control of biological function with high specificity and high spatiotemporal resolution. Mammalian cells and tissues can be sensitized to respond to light by a relatively simple and well-tolerated genetic modification using microbial opsins (light-gated ion channels and pumps). These can achieve fast and specific excitatory or...
متن کاملOptogenetics 3.0
Optogenetic methods use light to modulate the activities of target cells in vivo. By improving inter- and intracellular trafficking of light-sensitive switch proteins called opsins, Gradinaru et al. (2010) have developed a new generation of optogenetic tools capable of regulating the activity of targeted neurons with exquisite precision and efficiency.
متن کاملCorrigendum: Optogenetics
I was fascinated by the acute and insightful observations of my mentor, Coby Schal, on how male cockroaches pursue females in the forest (Science 215, 1405–1407). Later, at Tsing Hua University, in trying to understand how the brain controls sexual behavior and reproduction, we serendipitously discovered that juvenile hormone synthesis in cockroaches is regulated by NMDA receptors. Knowing the ...
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ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2018
ISSN: 0959-4388
DOI: 10.1016/j.conb.2018.03.008